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KMID : 1123920020160010186
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 1 p.186 ~ p.191
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Immunoregulation Effect of KamiBohuh-tang
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Park Kyung-Mi
Jung Jin-Hong
Yoo Dong-Youl
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Abstract
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The purpose of this study is to prove the efficacy of KamiBohuh-tang(KBT) on immunoregulation and the possibility of KBT as an immunoadjuvant. KBT with solid feed was administered orally once a day for 7 days to an experimental group, a solution of salt and solid feed without KBT to a control group. After a week T cell, B cell, cytokines, nitric oxide and phagocytic activity are measured. KBT enhanced the proliferation of splenocytes and the subpopulation of Th cells in splenic T-Iymphocytes, but did not affect the proliferation of thymocytes. KBT decreased the subpopulation of T-Iymphocytes in splenocytes. KBT enhanced the production of interferon-γ. interleukin-2, interleukin-4 in mice serum and the phagocytic activity in peritoneal macrophages but it suppressed the production of nitric oxide. These results suggest that KBT is a potent prescription on immune response via the increase of the proliferation of splenocytes, the production of cytokines from splenic Th cells and the phagocytic activity in vivo.
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KEYWORD
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KamiBohuh-tang, splenocytes, thymocytes, nitric oxide, phagocytic activity, cytokines
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